Rieke Zinc® is highly reactive and is moisture and oxygen sensitive. Therefore, it is important to exclude atmospheric moisture and oxygen from the reactions. This guide contains the bare minimum amount of knowledge required to use Rieke Zinc®. If one is unfamiliar with inert atmosphere techniques, we strongly advise consulting a definitive source on the manipulation of air sensitive reagents before using this metal. Once inert atmosphere techniques are mastered, Rieke Zinc® can be successfully and easily applied to many new synthetic strategies.